MAPK8 and lung cancer: In the study of the mechanism of action, BJ mainly plays a role in lymphocytic leukemia through the PI3K/Akt signaling pathway (Zhang et al., 2011; Zhang et al., 2021), lung cancer through the NRF2 (Zhao et al., 2016; Xie et al., 2021) and JNK (Yang et al., 2013) signaling pathways.