Owing to several unique features suchas eclipsed π–π stacking structure, long-rangecrystal domain, and good biocompatibility, COFs have significant potentialto be utilized as excellent carriers for tumor detection substances.101,102 Porphyrin-based COF (p-COF), a synthesized aptasensor created byYan et al.,103 selectively and sensitivelybinds to the epidermal growth factor receptor (EGFR) to detect humanbreast cancer MCF-7 cells. This evidence concerns the gene EGFR and neoplasm.