We found a statistically significant association (p=0.02) between elevated PSA and the diagnosis of prostatitis when we compared the median PSA value between patients with BPH alone (PSA 11ng/ml, IQR 7-16) to patients with BPH associated with prostatitis (PSA 15ng/ml, IQR 9-24). This evidence concerns the gene KLK3 and male reproductive organ cancer.