SPOTLIGHT trial (NCT03504397): Platinum fluoropyrimidine chemotherapy (folinic acid, 5-fluorouracil and oxaliplatin: FOLFOX) or capecitabine plus oxaliplatin (CAPOX) are standard chemotherapy regimens for HER-2 negative, locally advanced unresectable or metastatic GC/GEJ adenocarcinoma (97, 98). The gene discussed is ERBB2; the disease is gastric cancer.