We incubated pseudovirus with 5 mg/mL of S. reticulata extract or vehicle control (DMEM) and then infected human ACE2 over-expressing BHK-21 cells; however, we observed no apparent difference in cells treated with S. reticulata compared with that of vehicle control 24 h post-infection, (Fig. 3B). The gene discussed is ACE2; the disease is infection.