In severe COVID-19 patients, high neutrophils with excessive expression of cytokines were noted and the dysregulated cytokines/receptors interplay among lung epithelial cells and immune cells correlated with disease severity (ANXA1/FPR2 and TNFSF13/TNFRSF1A interactions between club and macrophage or neutrophils, CXCL2/DPP4 interaction between club and T/NK cells, and ANXA1, C3, CXCL2, SAA1, and TNFSF13 expressions in lung epithelial cells) (61). This evidence concerns the gene ANXA1 and COVID-19.