CDK2 and breast cancer: Xie et al. demonstrated that alkaloids, flavonoids, coumarins, and terpenoids also present in our extract upregulated the expression of Kip/p27 leading to a decrease in cyclin-D, cyclin-E, and CDK2/4/6 proteins in the melanoma cancer cell lines (WM1361B and WM983A) [16], colon cancer cell lines (HCT-116, LoVo, and DLD-1) [12], and human breast cancer cell line (MCF-7) [37].