E2F2 and gastric cancer: Previous studies and the public database analysis indicate that E2F2 also plays a protective prognostic role in gastric cancer, but E2F2-deficiency in this study weakened the proliferation and migration of gastric cancer cell lines, a result consistent with the findings of previous studies (Manicum et al., 2018; Li et al., 2021a; Wang et al., 2016).