In comparison, PARADIGM-HF (Prospective Comparison of ARNI [Angiotensin Receptor–Neprilysin Inhibitor] with ACEi to Determine Impact on Global Mortality and Morbidity in Heart Failure) and PARAGON-HF (The Prospective Comparison of with ARB Global Outcomes in HF with Preserved Ejection Fraction) enrolled 18% and 16% of patients from Asia, respectively.5 Here, MME is linked to heart failure.