It can be classified into subtypes based on molecular markers, which include hormone positive, Her2 negative or hormone negative, Her2 positive, or triple negative, i.e., negative ER, PR, and her2, etc. The primary molecular targets in breast cancer are Estrogen Receptor alpha, Transferrin Receptor, and Epidermal Growth Factor 2 [30]. This evidence concerns the gene ESR1 and breast carcinoma.