Within OS, there is limited evidence around ALDH and its prognostic value. Greco et al. published a 2014 retrospective review of 10 bone sarcoma patients (three OS, five chondrosarcoma, and two Ewing sarcoma), reporting a high percentage of ALDH-high cells in all eight patients who had metastatic disease [25]. The gene discussed is LDHA; the disease is chondrosarcoma.