MAPT and Alzheimer disease: AD is a neurodegenerative inflammatory disorder leading to degeneration of the brain cells in two classified ways: (a) formation of the β-amyloid (Aβ) plaques in the neurons around the nucleus in the medial temporal lobe of the brain and (b) formation of the tau (τ) tangles in the neurofibrillary region causing the loss of many neurons from different part of the brain cells [1].