Among the top occurring genes TP53, ITGB3, KRAS, SYK, CASP8, PTK2, PTPN11, etc. (Figure 4b), two of them, CASP8 and PTPN11, have well-defined metabolic pathways highlighting the reduction of progression in AD, hence their homology modeling was carried out resulting in GMQE value 0.37 for CASP8 whereas 0.90 for PTPN11. Ramachandran plot for CASP8 and PTPN11 is shown in (Table 1) and (Figure 5). Here, TP53 is linked to Alzheimer disease.