Albumin-sericin nanoparticles (Alb-Ser NPs) further functionalized by complexing with poly-l-lysine/siRNA and hyaluronic acid were also used for delivery of siRNA targeting casein kinase 2 (CK2), Absent, Small, or Homeotic-Like (ASH2L), and Cyclin D1 (CCND1) genes to the laryngeal cancer Hep-2 cells. The gene discussed is ALB; the disease is laryngeal carcinoma.