Mechanisms underlying this resistance involve the overexpression of Cell Retinoic Acid Binding Protein 2 (CRABP2), which promotes the binding of BAX and PARKIN in gastric cancer cells, thereby facilitating ubiquitin-mediated BAX degradation and weakening of mitochondrial apoptosis (Tang et al., 2022). The gene discussed is CRABP2; the disease is gastric cancer.