TRPC5, involved in ATP-binding cassette subfamily B member 1 (ABCB1)-mediated overexpression of ABCB and cyclin D1, induces nuclear β-catenin accumulation, leading to resistance of gastrointestinal tumor cells to 5-Fluorouracil (5-FU) (Campbell et al., 2018). Here, ABCB1 is linked to digestive system neoplasm.