Sodium-potassium ATPase (Na+/K+ ATPase), an ion pump responsible for maintaining cellular ion balance, has been investigated, revealing that silencing ATP1B3 leads to reduced expression of phosphatidylinositol 3-kinase (PI3K), protein kinase B (AKT), and phosphorylated AKT (p-AKT), ultimately inhibiting the proliferation and migration of gastric cancer cells (Li et al., 2017). Here, AKT1 is linked to gastric cancer.