HRC and gastric cancer: Notably, the histidine-rich calcium-binding protein (HRC), a calcium-binding protein, has been observed to modulate the Raf/MEK/ERK pathway through calcium (Ca) and calmodulin (CaM) signaling, thereby impacting the epithelial-mesenchymal transition (EMT) in gastric cancer (GC) cells (Wang et al., 2022).