Additionally, although Kv11.1 is undetectable in normal gastric tissue, it is detected in GC tissue (Ding et al., 2010) and has been shown to promote GC proliferation and tumor occurrence both in vitro and in vivo, regulating the secretion of vascular endothelial growth factor 1 (VEGF-1) through the AKT-dependent pathway (Shao et al., 2008; Crociani et al., 2014). The gene discussed is KCNH2; the disease is gastric cancer.