For instance, the knockout of latent transforming growth factor-beta binding protein 2 (LTBP2) augments ferroptosis in gastric cancer cells via the KEAP1/NRF2 pathway (Wang et al., 2022), while Xiaojian Decoction, a traditional Chinese medicine, can alleviate gastric mucosal injury by suppressing ferroptosis through the activation of the Keap1/Nrf2 signaling pathway in normal gastric tissue (Chen et al., 2022). This evidence concerns the gene KEAP1 and gastric cancer.