TYR and Parkinson disease: Moreover, these metabolic irregularities are directly associated to the onset and treatment of various human diseases, including Parkinson's disease, melanoma, and albinism.2 Research has indicated that inhibiting tyrosinase activity to impede melanin production is an effective approach for treating pigmentation-related skin disorders.3 Hydroquinone, a potent tyrosinase inhibitor, was first proposed by Oettel4 in 1936 for its skin-whitening effects.