MAPT and Alzheimer disease: For example, in AD, hyperphosphorylated tau accumulation in neurons and glial activation in response to neuroinflammation result in significant changes in the cytomorphology of neurons and glia (microglia and astrocytes), respectively.5,6 These changes are expected to affect the diffusion rate of water inside neurons and glia, and it is not known whether the separate contributions of neurons and glia cells can be disentangled in DW-MRI experiments.