MAPT and juvenile Huntington disease: HTT aggregates have been described in the gastrointestinal tract of mouse models of Huntington’s disease,65 and the loss of enteric neuropeptides has been linked to weight loss in these mice.66 Nevertheless, although well-established within the field of dementias, where the functions of Tau are well characterized, it remains mostly speculative in Huntington’s disease and the rate at which changes in brain pathology are reflected in plasma versus CSF total-Tau levels remains to be investigated.