Growth hormone (GH), a key hormone regulating postnatal growth, plays a major role in metabolic function after puberty [1], and GH deficiency is associated with increased adiposity, accumulation of fat in the liver, and the development of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH), which is reduced by GH replacement [2]. The gene discussed is GH1; the disease is metabolic dysfunction-associated steatotic liver disease.