An overview of amyloid pathogenesis is provided in Figure 6, with initial shifts in the cleavage of the integral membrane protein amyloid precursor protein (APP) by β Secretory enzyme (BACE1) and γ Secreting enzyme, ultimately yielding insoluble Aβ fibrils that oligomerize, spread into synapses, and thereby disrupt synaptic signaling. Here, APP is linked to amyloidosis.