In both the TCGA and CGGA datasets, TREM1 expression was found to be positively correlated with HCK, interferon, LCK, MHC-I, MHC-II, and STAT1 metagenes but negatively correlated with IgG metagenes in glioma (Figure 4C and Supplementary Figure 5). This evidence concerns the gene HCK and central nervous system cancer.