TREM1 and cancer: A majority of steps in the cancer immunity cycle were up-regulated in the high-TREM1 subgroup, including the release of cancer cell antigens (Step 1), priming and activation (Step 3), and trafficking of immune cells to tumors (Step 4) (CD8+ T cell recruiting, macrophage recruiting, and Th1 cell recruiting), infiltration of immune cells into tumors (Step 5), recognition of cancer cells by T cells (Step 6), and killing of cancer cells (Step 7) (Figure 5B and Supplementary Figure 10B).