Therefore, it is possible that the antibody effects observed in vitro are necessary to cause the disease; thus, IgG1-dependent cross-linking and internalization of IgLON5 clusters would be followed by alteration of the cytoskeletal architecture and would lead ultimately to tau aggregation and phosphorylation through common pathways described for neurodegenerative diseases. This evidence concerns the gene MAPT and neurodegenerative disease.