Loading ghosts with shLAMP2a allows for the stable modulation of peroxiredoxin 1 (PRDX1) and CREB-regulated transcription coactivator 1 (CRTC1) within TAMs, both of which serve as responsive factors activating the ROS signaling pathway, thereby inducing macrophage inflammation and controlling tumor growth (180). The gene discussed is PRDX1; the disease is neoplasm.