For instance, the co-localization of CKLF-like marvel transmembrane domain-containing protein 6 (CMTM6) with programmed cell death ligand 1 (PD-L1) on the plasma membrane and recycling endosomes of cancer cells prevents PD-L1 lysosomal degradation, thereby inhibiting the activity of tumor-specific T cells (18). This evidence concerns the gene CD274 and cancer.