High tumor B7-H3 expression was significantly associated with pT stage (p = 0.02, Fig. 1C and Table S1), lymph node metastasis (p=0.027, Table S1), lymphovascular invasion (LVI, p = 0.035, Table S1), distant metastasis (p=0.001, Fig. 1D) and EGFR expression (p=0.019, Table S1). This evidence concerns the gene CD276 and neoplasm.