However, retrospective analysis of the database indicated that AKR1B10 downregulation in colorectal cancer was not correlated with tumor types, histological stages, cell differentiation and lymph nodes and distant metastasis; AKR1B10 expression in colorectal cancer did not have effects on overall and disease-free survival and in various survival analysis stratified by clinicopathological parameters. Here, AKR1B10 is linked to colorectal cancer.