AKR1B10 and colorectal cancer: Out of 592 cases, AKR1B10 was not detected (negative) in 374 (63.18%) cases, weakly positive in 146 (24.66%) cases, and positive in 72 (12.16%) cases (Figure 1), indicating the downregulation of AKR1B10 in a large number of colorectal cancer tissues.