AKR1B10 is not expressed in normal breast, lung and pancreas tissues, but upregulated in tumors developed from these organs, including breast cancer 31, pancreatic cancer 32, lung squamous cell carcinomas and adenocarcinomas 33, and hepatocellular carcinoma 6, 34, 35. This evidence concerns the gene AKR1B10 and hepatocellular carcinoma.