AKR1B10 and colorectal cancer: In mice, targeted deficiency of AKR1B8 (an orthologue of human AKR1B10) leads to high susceptibility to dextran sulfate sodium (DSS)-induced colitis and associated colorectal tumorigenesis 39; in humans, AKR1B10 was reported as a negative prognostic marker of colorectal cancer 40.