It was reported that METTL16 played a suppressor role in pancreatic adenocarcinoma by METTL16-p21 signaling axis.23, 24 High expression of METTL16 predicted a poor outcome of soft-tissue sarcomas.25 To date, only a limited number of studies have been conducted to elucidate the association between METTL16 and EOC, which have revealed compelling evidence suggesting that METTL16 may function as a tumor suppressor in the progression of EOC10. This evidence concerns the gene METTL16 and neoplasm.