Huang et al. reported that tRF/miR-1280, a 17-nt fragment from tRNALeu and pre-miRNA, can directly bind Notch ligand JAG2 in colorectal cancer (CRC) to further inhibit the Notch signaling pathway and reduce tumorigenesis during CRC progression, formation and transfer104. Here, JAG2 is linked to colorectal carcinoma.