Further exploring the possible signaling pathways of DEPs in OSCC through KEGG, we found that OSCC may share the same biological pathways as small cell lung cancer, toxoplasmosis, amoebiasis and human papillomavirus infection, and the DEPs may participate in pathways of focal adhesion, PI3K-Akt signaling pathway and ECM- receptor interaction. The gene discussed is AKT1; the disease is amebiasis.