And 16 proteins were down-regulated in the tumor including CAV1, NCAM1, PLG, CHL1, LAMA2, LAMA4, LAMA5, LAMB2, LAMC1, LAMC3, SNCA, CRYAB, HSPD1, LRP1, BCL2, NCAM2 (P<0.05). The gene discussed is BCL2; the disease is neoplasm.