Then, immune checkpoints analysis shown that UBE2C had a negative correlation with immune checkpoints, such as CD274(PD-1), PDCD1(PD-L1), CTLA4, TIGIT, LAG3, HAVCR2, and PDCD1LG2 in a great many cancers (Figure 9B). This evidence concerns the gene PDCD1LG2 and cancer.