To date only two mouse models relevant to these overgrowth syndromes have reported increased body growth, which are heterozygous single mis-sense loss-of-function mutations of either EZH2 (45) or DNMT3A (46), suggesting that while the complete loss of these KMTs or DNMTs is detrimental, it is conceivable that a more subtle, partial reduction of activity could be growth-promoting. The gene discussed is DNMT3A; the disease is overgrowth syndrome.