The proposed independent predictors of HH persistence in men PRLomas include higher baseline PRL levels (135, 136, 141, 142), larger tumor size (16, 135, 136, 141, 142), lower baseline testosterone levels (135, 140–142), hypopituitarism (140, 142), and visual field defect (140). This evidence concerns the gene PRL and prolactin-producing pituitary gland adenoma.