GPER1 and posterior cortical atrophy: Hh pathway is a key signaling pathway involved in stemness and associated to relapse and bad prognosis (11) Not much is known about GPER and its regulation of Hh transcriptional factors, nevertheless, this receptor can trigger signaling cascades initiated in plasma membrane (24) leading to a pro-tumorigenic environment that promote angiogenesis (25); however, there is a limited information about biological significance of GPER and relation with Hh pathways in PCa tissue.