LRP5 and disease of the tendon: Wnt3a, β-catenin, Lrp5, and Tcf1 are expressed in chondrocyte like cells and ossified deposits in animal models and some clinical samples of tendinopathy, which are associated with failure of ossified tendon healing; In addition, Wnt3a increased the expression of ALP activity, calcium nodule formation, and osteogenic markers in rTDSCs [46].