Its aging is an unavoidable gradual process, regardless of the causes of skin aging; dull skin, thinning, wrinkle production, and reduced elasticity are typical of skin aging, which is mainly determined by the relative content of water and hyaluronic acid, collagen, and elastin in the extracellular matrix (ECM) of the dermis and the structural stability of collagen fibers and elastin fibers (Lee et al., 2008). Here, ELN is linked to skin aging.