Chlorogenic acid (400 μM) inhibits the binding of annexin A2 to the p50 subunit, thereby inhibiting the expression of downstream antiapoptotic genes cIAP1 and cIAP2 of the NF‐B signaling pathway in A549 cells. Furthermore, chlorogenic acid inhibited the binding of annexin A2 to Actin, potentially inhibiting tumor cell cycle and migration. The gene discussed is BIRC3; the disease is neoplasm.