Moreover, caffeine mediates immune suppression of proinflammatory cytokine production, including tumor necrosis factor‐alpha (TNF‐α), interleukin 2 (IL‐2), and interferon‐gamma (IFN‐γ), which are crucial for the onset and progression of autoimmune diseases (DePaula & Farah, 2019). Here, IL2 is linked to autoimmune disease.