An upregulation of COX1, among other pro-inflammatory markers, was observed in the RP murine model rd10. The inhibition of COX1, by the NSAID SC-560, or its genetic ablation in the rd10 mutant mouse could reduce the release of pro-inflammatory cytokines TNFα and IL-1β, slow photoreceptor degeneration and increase visual acuity (Yang W. et al., 2020). This evidence concerns the gene PTGS1 and retinitis pigmentosa 1.