Among the inflammatory mediators, tumor necrosis factor alpha (TNFα) and its receptors TNFR1 and 2 were found strongly upregulated in RP animal models and also in serum and aqueous humor of RP patients (Appelbaum et al., 2017; Lu et al., 2020; Okita et al., 2020). Here, TNFRSF1A is linked to retinitis pigmentosa 1.