Using coimmunoprecipitation and deacetylation assays, and with the help of knockdown and overexpression experiments of HDAC5, Sharma et al. demonstrated the role of HDAC5 in modulation of transcriptional activity of SATB1, a genome organizer which recruits transcriptional modellers, and in promotion of aggressive features of lung adenocarcinoma in cell lines and orthotopic mouse xenograft models [92]. The gene discussed is HDAC5; the disease is lung adenocarcinoma.