While SIRT1, SIRT2, and SIRT5 may have tumour-promoting or tumour-suppressing effects depending on the tumour histology and cellular context [32], the NCI-60 panel included melanoma cell lines, and therefore the differences in SIRT2 associations with dasatinib response may be caused by factors other than tumour specificity. This evidence concerns the gene SIRT1 and melanoma.