The calculated drug sensitivity scores (DSS21) showed that ETV6/RUNX1 t(12;21) cell lines were more sensitive to CQ, HCQ and Lys-05, and to PIK-III and ATG14i than other pre-B-ALL cell lines (Table 1 and Fig. 2b, c). The gene discussed is RUNX1; the disease is acute lymphoblastic leukemia.