CASP3 and acute lymphoblastic leukemia: We then studied apoptosis in pre-B-ALL cell lines SEM and RCH-ACV, and T-ALL cell lines P12-ICHIKAWA and CCRF-CEM treated with all drug combinations over time monitored by Caspase 3/7 activation and live-cell imaging analysis (Figs. 3e and 4c, respectively, and Supplementary Fig. 5 for cell confluence and an image example).