Further analysis revealed that in the TCGA CRC and GSE110224 datasets, the expression level of TRIP6 was significantly positively correlated with the expression of GAPDH, PKM, GPI and TPI1, while the expression of TRIP6 was significantly positively correlated with SLC2A1, PFKM and ALDOA only in the TCGA CRC dataset (Fig. 6D, P < 0.05). The gene discussed is PFKM; the disease is colorectal carcinoma.