In addition, in the TCGA CRC dataset, the expression of TRIP6 was significantly positively correlated with the expression of LRPAP1, LPL, FGFR1, TNFRSF21, APP, JAG1, COL3A1, PDGFA, SLCO2A1, VAV2, S100A4, and TIMP1, but significantly negatively correlated with the expression of ITGAV and CXCL6 (Fig. 9A, P < 0.05). The gene discussed is APP; the disease is colorectal carcinoma.