As such, we profiled soluble ligands in the TCM and indeed there were significantly higher levels of soluble B7-H6, the ligand for NKp30, in the tumour of obese (n = 8) OAC patients compared to non-obese (n = 6), suggesting that NKR ligand shedding may be exacerbated in obese OAC patients; non-obese versus obese (47.87 pg/ml vs. 128.5 pg/ml, p = 0.04) (Fig. 1e). This evidence concerns the gene NCR3 and neoplasm.