Previous studies had observed genetic (Wang et al. 2016) and protein (Cottone et al. 2020) loss of CDKN2A-p16 in different chordoma cohorts, and we also detected a heterozygous deletion that involved the depletion of CDKN2A/2B/2C and gain of CCND2 and CDK6 (Table 2). This evidence concerns the gene CDKN2A and chordoma.