In order to detect possible changes arising during the course of the infection, we tested a group of patients with an acutely diagnosed infection (early stage infection, persistent IgM serological positivity (n = 30)) and a group of patients followed after the late stage of the infection (serologically characterized by the positivity of markers of advanced infection p58, p83 or lipid antigens (n = 30)). This evidence concerns the gene RHOBTB2 and infection.