After quality control and filtering, single-cell transcriptomes for 18,113 cells from the lymph node tissues of three DLBCL (DLBCL1, DLBCL2, DLBCL3) and three rLN (rLN1, rLN2, rLN3) were obtained for subsequent analysis. This evidence concerns the gene RLN3 and diffuse large B-cell lymphoma.