In many solid tumors and lymphohematopoietic neoplasms, TIM3/Galectin-9 pathway is closely related to CD8+TILs exhaustion, tumor immune evasion, and poor prognosis, such as breast cancer [26], glioma [27], and acute myeloid leukemia [28]. The gene discussed is LGALS9; the disease is acute myeloid leukemia.