Cellular communication analysis by CellChat demonstrated that there were many interactions among macrophages and five clusters of CD8+TILs in DLBCL (Fig. 5c), including a variety of ligand-receptor pairs related to chemokine, such as CXCL9-CXCR3, and macrophages interacted with CD8-5 cells and CD8-4 cells through HAVCR2-LGALS9. This evidence concerns the gene HAVCR2 and diffuse large B-cell lymphoma.