A recent study has shown that the abnormal expression of glycolysis-related signature genes in DLBCL is related to the infiltration of CD8+TILs and TIM3 expression [46], suggesting the possible role of glycolysis in TIM3/Galectin-9 pathway mediated CD8+TILs exhaustion in DLBCL. Here, CD8A is linked to diffuse large B-cell lymphoma.