We previously analyzed the characteristics of TME in DLBCL by flow cytometry and found that CD8+TILs may be an important cause of the heterogeneity in DLBCL [9], and the proportion of CD8+TILs and the expression of PD-1 play a pivotal role in prognosis evaluation [10]. The gene discussed is CD8A; the disease is diffuse large B-cell lymphoma.