The correlation between the expression of TIM3-ligand genes (LGALS9, HMGB1, CEACAM1, PTDSS1, PTDSS2) and the proportion of exhausted CD8+TILs in DLBCL was analyzed by scRNA-seq (Fig. 4a, b). The gene discussed is HMGB1; the disease is diffuse large B-cell lymphoma.