Migraine duration was positively correlated with serum HIF-1α (r = 0.712, p < 0.0001), and IL-6 levels (r = 0.476, p < 0.0001), HADS-A (r = 0.554, p < 0.0001), HADS-D (r = 0.452, p < 0.0001), and HIT-6 scores (r = 0.505, p < 0.0001) in CM patients with MOH and EM patients. The gene discussed is HIF1A; the disease is migraine disorder.