The number of monthly migraine headache days was positively correlated with serum LPS (r = 0.512, p < 0.001), HIF-1α (r = 0.622, p < 0.0001), VE-cadherin (r = 0.437, p < 0.0001), IL-6 levels (r = 0.474, p < 0.0001), migraine duration (r = 0.676, p < 0.0001), HADS-A (r = 0.439, p < 0.0001), HADS-D (r = 0.417, p < 0.0001), HIT-6 (r = 0.513, p < 0.0001) and MigSCog scores (r = 0.424, p < 0.0001) in CM patients with MOH and EM patients. Here, IL6 is linked to migraine disorder.