Here, we firstly reported that adrenarche-accompanied rise of sex steroid precursors plays a key role in preventing the incidence of NAFLD in early life of females by converting into active androgens and inactivating hepatic sterol regulatory element-binding transcription factors 1 (SREBF1, also known as SREBP1) signaling. The gene discussed is SREBF1; the disease is metabolic dysfunction-associated steatotic liver disease.