Accordingly, we proposed a putative mechanism for adrenarche-accompanied androgens to prevent NAFLD in young female rats and shown in Fig. 10B. Inactivating SREBF1 signaling seems to be the key mechanism in mediating adrenarche-accompanied androgens to prevent hepatic de novo fatty acid biosynthesis, but through which mechanism it suppresses hepatic cell cycle progression is not clear (Fig. 10B). The gene discussed is SREBF1; the disease is metabolic dysfunction-associated steatotic liver disease.