Secondly, although through integrative analysis we identified that AR-SREBF1 transcriptional networks appears to play a central role in mediating adrenarche-accompanied adrenal androgens to prevent the incidence of NAFLD in young females, it still requires further validation using like liver-specific Ar/Srebf1 knockout animal models. Here, SREBF1 is linked to metabolic dysfunction-associated steatotic liver disease.