ACACB and Cowden disease: Although there was no clear clustering of the differentiating genes in SB-CD when analyzed separately (Supplementary Figure 3A), we observed a commonly shared network between ACACB, CYP4F2, GALC, HOXD4, PDCD6IP, SPINT4, and SMYD4 in C-CD patients (Supplementary Figure 3B).