Interestingly, ALS is characterized by the accumulation of protein inclusions, often consisting of superoxide dismutase 1 (SOD1), TAR DNA-binding protein 43 (TDP-43), and fused-in-sarcoma (FUS), pathogenic proteins all found in exosomes isolated from CSF and plasma of ALS patients [69,70]. Here, TARDBP is linked to amyotrophic lateral sclerosis.