BIN1 and Alzheimer disease: As BIN1iso1 also contains exon 7, neuron loss is a possible explanation, but Taga and colleagues argue in support of an astrocyte-specific effect, based on observations of selective loss of astrocytes expressing exon 7 containing BIN1 in human AD brains versus controls, without differences between groups in the total number of astrocytes or the number of neurons expressing BIN1 [58].