Direct comparison of the neuronal and astrocytic rescue of NPC pathology revealed an increased survival upon expression of NPC1 in neurons compared with astrocytes, but combining NPC1 expression in astrocytes and neurons had additive effects in prolonging the survival of Npc1−/− mice (until the age of 10 months), improving weight loss and delaying ataxia and tremor phenotypes [86]. This evidence concerns the gene NPC1 and Tremor.