One such gene of interest is vacuolar protein sorting 35 ortholog (VPS35), where an aspartic acid to asparagine mutation at residue 620 (D620N) (p.Asp620Asn, c.1858G > A) causes a late-onset, autosomal dominant form of PD that was originally identified in Swiss and Austrian families [7,8]. Here, VPS35 is linked to Parkinson disease.