NUCB1 and pancreatic insulinoma: NUCB1/NLP-like immunoreactivity was reported in the central nervous system and peripheral tissues, including endocrine cells of the anterior pituitary of rats and mice1,28, mouse insulinoma MIN6 cell line and mouse pancreatic beta cells17 as well as testis, ovary, and head kidney interrenal cells2 and pituitary of goldfish18.